Thursday, September 03, 2020

Steroids can save lives of patients with severe covid-19, earning WHO endorsement

 

Steroids can save lives of patients with severe covid-19, earning WHO endorsement

New studies confirm British findings and build on them to show multiple steroids are effective.

Dexamethasone was the first steroid shown to be effective in severely ill covid-19 patients. (Nati Harnik/AP)
Dexamethasone was the first steroid shown to be effective in severely ill covid-19 patients. (Nati Harnik/AP)
September 2, 2020 at 12:37 PM EDT

Cheap, widely available steroid drugs reduced the number of deaths in the sickest patients with covid-19, show a trio of newly published clinical trials.

The World Health Organization, citing evidence from these and similar trials, announced Wednesday it strongly recommends doctors use the medications to combat severe or critical forms of disease caused by coronavirus infections.

Finding a treatment that saves lives is “electrifying … it gives us hope. Maybe we’re gaining on this virus,” said Todd W. Rice, a critical care physician at Vanderbilt University Medical Center who was not involved in the studies.

WHO’s decision brings the international agency in line with the U.S. National Institutes of Health, which earlier this summer recommended use of a synthetic steroid, dexamethasone, to treat hospitalized patients who require ventilators or oxygen.

The evidence that persuaded the WHO included a meta-analysis, sponsored by the organization, which evaluated three new studies, plus four other randomized, controlled trials. Each trial involved a medication from the family of anti-inflammatory drugs called corticosteroids.

“These three trials, and then the World Health Organization meta-analysis, sets steroids as the standard and the expectation that patients are critically ill will get treated with this,” Rice said.

The WHO review concluded corticosteroids reduced deaths in critically ill patients by 20 percent — a drop from 2 deaths per 5 patients to 1 in 3. It found that another steroid, hydrocortisone, had benefits on par with those of dexamethasone.

“Corticosteroids are the only treatment that has been conclusively demonstrated to reduce mortality in patients with covid-19,” said Jonathan Sterne, an author of the meta-analysis and an expert in medical statistics at Britain’s University of Bristol.

“These results strengthen the evidence that doctors should treat critically ill covid-19 patients with corticosteroids, unless there is a strong reason not to do so based on the circumstances of the individual patients,” he said.

Dexamethasone was the first medication shown to increase the odds of survival in patients with severe covid-19 when initial outcomes from a British clinical trial, named Recovery, were published in June.

The similar benefits shown by these new studies was a welcome confidence boost to doctors who had been using corticosteroids to treat patients based on the earlier results.

“The Recovery trial was a fantastic trial. But even though it was a great trial, it was viewed by many as simply one trial,” said University of Pittsburgh critical care doctor Derek C. Angus, an author of the eight-country hydrocortisone trial. “People wondered about generalizability.”

To steroids’ true believers within the medical profession, it was compelling, he said, but not enough to persuade all doctors.

The new findings should resolve remaining uncertainty. “When we see that this is this very consistent signal of benefit across different trials, that’s very exciting,” said Hallie Prescott, a pulmonary and critical care doctor in the University of Michigan Health System.

“At the beginning of this pandemic, we were hesitant and we advised against” corticosteroids due to shortcomings in past respiratory illnesses, said Janet V. Diaz, a physician and clinical management lead for the WHO’s health emergencies program, during a Facebook Live video Wednesday.

But the organization changed its advice, she said, based on pooled trial results that indicate “if you give corticosteroids, you will have 87 fewer deaths per 1,000 patients” in the worst cases.

The three trials published Wednesday, each in the Journal of the American Medical Association, involved covid-19 patients in intensive care units from across the planet. One trial studied dexamethasone in 299 patients in Brazil; a second in France tested hydrocortisone in low doses in 76 patients against 73 who received a placebo; the third analyzed 379 patients to test hydrocortisone in the United States and seven other countries.

All three trials halted after the British results became public in June. Trial steering committees around the world concluded it would be uncomfortable, if not unethical, for doctors to give patients placebos in randomized trials.

Because of that, these steroid trials stopped short of enrolling enough patients for their results to be as statistically powerful as desired.

“Although the individual trials weren’t necessarily conclusive, because they hadn’t run to term, they were all pointing in the right direction,” Angus said. He added: “It feels like the first fresh piece of fairly consistent, uncomplicated, straightforward, good news about something concrete to do for the sickest of patients."

Similar results in dexamethasone and hydrocortisone indicate corticosteroids are helpful as a class of drugs. Such flexibility may allow hospitals to avoid the shortages of remdesivir, an antiviral coronavirus therapy.

The NIH recommends treatment with the steroid methylprednisolone, for instance, if dexamethasone is not available; NIH said in a statement Wednesday its working groups will propose updates based on the latest research findings.

“The steroids are pretty much readily available, and they’re not really expensive,” Rice said. That’s true not only in the United States but also in lower-income countries, where the WHO guidelines will carry significant weight.

While providing a strong foundation for corticosteroid treatment, the studies left several questions unanswered. One of the biggest is more clearly determining which patients are most likely to be helped.

The WHO guidance defines critical covid-19 by conditions, such as acute respiratory distress syndrome or septic shock, that require life-sustaining therapies. Signs of severe covid-19 include low blood oxygen and respiratory distress that prevents, for instance, speaking in complete sentences.

“This sets forth that the sickest, the most severely ill in the ICU appear to be clearly benefited by this,” Rice said. Even within that group, however, there may be certain patients for whom “giving steroids isn’t the right thing to do.”

Doctors are likely to agree an ICU patient on mechanical ventilation or significant respiratory support should receive steroids, Prescott said. But she said she will make case-by-case decisions for her “gray zone” patients — those who receive a few liters of oxygen.

“Just because steroids work in sicker patients does not mean to say that we should be cavalierly starting steroids in every patient,” Angus said. Many patients “don’t need these big-gun drugs that suppress the immune system broadly.”

Steroids may not help low- or moderate-risk patients, and some doctors worried about potential harm in those cases. The Recovery trial did not observe a benefit in patients with mild covid-19.

“We always have a concern when we give steroids to patients in general, because steroids depress the immune system,” Nahid Bhadelia, medical director of the special pathogens unit at Boston Medical Center, told The Post in June. “They carry the risk of making the current infection worse and increase the chance of another infection taking a foothold.”

Steroids do not attack the virus itself. Instead, they decrease the body’s defensive response, which in severe coronavirus cases can spiral into out-of-control inflammation. Whether steroids should be given in combination with other treatments, such as remdesivir, that directly fight the pathogen is another open question.

“We don’t know that for sure, because we don’t have rigorous studies showing us that,” Rice said.

Steroid drugs can also cause unwanted side effects, such as delirium or high blood sugar levels.

WHO experts emphasized these are clinical guidelines for doctors, not for individuals. “This is not for someone to do over-the-counter who’s caring for themselves” said Maria Van Kerkhove, a WHO infectious-disease epidemiologist. Bothersome but mild symptoms do not reach the threshold of disease recommended for corticosteroid treatments.

Future studies will refine duration and drug dosages, the doctors said. A trial in Denmark has already been launched, Prescott said, to evaluate high vs. low doses of steroids.

Read more:

Basmati Rice Market Size and Forecasts Research Report 2020-2026

 

Basmati Rice Market Size and Forecasts Research Report 2020-2026
Published: 19 hours ago   Author: Ashwin Naphade  Category: #News

Basmati Rice Market Size and Forecasts Research Report 2020-2026

Market Study Report, LLC offers a latest study on ' Basmati Rice market' featuring a holistic view of the market size, industry share, profit estimates, SWOT analysis and the regional landscape of the business. The report precisely expounds key challenges and future growth prospects of the market, while highlighting the current competitive scene and analyzes the expansion strategies adopted by leading market players.

The research report on Basmati Rice market offers a granular analysis on existing market trends, as well as drivers that are slated to catalyze the market growth during the forecast period. It also highlights major market segments, and key manufacturers. Furthermore, the report also comprises of the restraints which may hamper the remuneration over the analysis timeframe. The report throws light on the business overview keeping in mind the effects of COVID-19 pandemic on the industry vertical.

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Summary of the geographical landscape of the Basmati Rice market:

  • The regional landscape of the Basmati Rice market has been fragmented into North America, Europe, Asia-Pacific, Southeast Asia, Middle East and Africa, South America.
  • The report uncovers detailed country-wise analysis.
  • Pivotal insights such as market share, sales generated, revenue amassed, and predicted growth rate are also incorporated in the report.

Analyzing the competitive landscape of Basmati Rice market:

  • Companies which define the competitive terrain of the Basmati Rice market are
    • Kohinoor Foods Ltd
    • Golden Foods
    • DUNAR
    • REI Agro Ltd
    • LT Foods Ltd
    • KRBL Ltd
    • Amar Singh Chawalwala
    • Lakshmi Group
    • R.S.Mills
    • Pari India
    .
  • The research provides detailed information pertaining to production, value, product price, and gross margin.
  • The report also encompasses the market share and sales generated by each company profiled.

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Additional features of the Basmati Rice market report:

  • As per the report, the application landscape of the Basmati Rice market is bifurcated into
    • Direct Edible
    • Deep Processing
    .
  • The market share, consumption rate, and estimated growth rate of each application fragment are mentioned.
  • The document segments the type scope of Basmati Rice market into
    • Indian varieties
    • Pakistani varieties
    • Kenyan variety
    • American varieties
    .
  • Pivotal insights pertaining to estimated growth rate, market share, production, current and predicted value, and market volume forecast of each type fragment is cited in the report.
  • The report highlights suppliers of raw materials, buyers, and distributors operating in Basmati Rice market.
  • It also analyzes expenditures on labor, manufacturing, and production.
  • The report encompasses a new project feasibility analysis which is structured using SWOT analysis and Porter’s Five Force Analysis.

Table of Contents:

  • Global Basmati Rice Market Overview
  • Market Competition by Manufacturers
  • Production, Revenue (Value) by Region
  • Supply (Production), Consumption, Export, Import by Regions
  • Production, Revenue (Value), Price Trend by Type
  • Market Analysis by Application
  • Manufacturing Cost Analysis
  • Industrial Chain, Sourcing Strategy and Downstream Buyers
  • Marketing Strategy Analysis, Distributors/Traders
  • Market Effect Factors Analysis
  • Global Basmati Rice Market Forecast

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Ready to Eat Rice Market to See Huge Growth by 2025 | Seneca Foods, Minute Rice, VegaFoods, Tastic

 

Ready to Eat Rice Market to See Huge Growth by 2025 | Seneca Foods, Minute Rice, VegaFoods, Tastic

Ready to Eat Rice Market

Ready to Eat Rice Market to See Huge Growth by 2025 | Seneca Foods, Minute Rice, VegaFoods, Tastic

Latest Study on Industrial Growth of COVID-19 Outbreak-Global Ready to Eat Rice Market 2019-2025. A detailed study accumulated to offer Latest insights about acute features of the COVID-19 Outbreak- Ready to Eat Rice market. The report contains different market predictions related to market size, revenue, production, CAGR, Consumption, gross margin, price, and other substantial factors. While emphasizing the key driving and restraining forces for this market, the report also offers a complete study of the future trends and developments of the market. It also examines the role of the leading market players involved in the industry including their corporate overview, financial summary and SWOT analysis.

COVID-19 Outbreak- Ready to Eat Rice Market Study guarantees you to remain / stay advised higher than your competition. With Structured tables and figures examining the COVID-19 Outbreak- Ready to Eat Rice, the research document provides you a leading product, submarkets, revenue size and forecast to 2025. Comparatively is also classifies emerging as well as leaders in the industry. Click To get SAMPLE PDF (Including Full TOC, Table & Figures)

The Major Players Covered in this Report: Seneca Foods Corp., Minute Rice, Vala Thai Food Co., Shanghai Meilin, VegaFoods, Tastic, Tasty Bite, Yamie, Marbour, Mars Inc & Gu Da Sao

The Industry assessment helps to understand the demand in the market, and the state of competition. To better derive facts company profiling is , specifications covered for each player that shows product picture, sales, market share and contact information of various regional, international and local vendors of COVID-19 Outbreak-Global Ready to Eat Rice Market. The market is frequently developing impact with the rise in scientific innovation and M&A activities in the industry. Additionally, many local and regional vendors are offering specific application products for varied end-users. The new merchant applicants in the market are finding it hard to compete with the international vendors based on reliability, quality and modernism in technology.

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The titled segments and sub-section of the market are highlighted below:

Detailed analysis of COVID-19 Outbreak-Global Ready to Eat Rice market segments by Types: , Indian Style, Chinese Style & Other Styles

Detailed analysis of COVID-19 Outbreak-Global Ready to Eat Rice market segments by Applications: Supermarkets / Hypermarkets, Independent / Specialist Retailers, Restaurant and Hotels & Others

Major Key Players of the Market: Seneca Foods Corp., Minute Rice, Vala Thai Food Co., Shanghai Meilin, VegaFoods, Tastic, Tasty Bite, Yamie, Marbour, Mars Inc & Gu Da Sao

Regional Analysis for COVID-19 Outbreak-Global Ready to Eat Rice Market:
North America (United States, Canada and Mexico)
Europe (Germany, France, UK, Russia and Italy)
Asia-Pacific (China, Japan, Korea, India and Southeast Asia)
South America (Brazil, Argentina, Colombia etc.)
Middle East and Africa (Saudi Arabia, UAE, Egypt, Nigeria and South Africa)

Furthermore, the years considered for the study are as follows:
Historical year – 2014-2019
Base year – 2019
Forecast period** – 2020 to 2025 [** unless otherwise stated]

**Moreover, it will also include the opportunities available in micro markets for stakeholders to invest, detailed analysis of competitive landscape and product services of key players.

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– Comprehensive valuation of all prospects and threat in the COVID-19 Outbreak-Global Ready to Eat Rice market.
– In depth study of industry strategies for growth of the COVID-19 Outbreak- Ready to Eat Rice market-leading players.
– COVID-19 Outbreak- Ready to Eat Rice market latest innovations and major procedures.
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– Conclusive study about the growth conspiracy of COVID-19 Outbreak- Ready to Eat Rice market for forthcoming years.

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5. Exactly how do the most important companies and mid-level companies make income within the Market?
6. Complete research on the overall development within the COVID-19 Outbreak- Ready to Eat Rice Market that helps you elect the product launch and overhaul growths.

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Detailed TOC of COVID-19 Outbreak- Ready to Eat Rice Market Research Report-

– COVID-19 Outbreak- Ready to Eat Rice Introduction and Market Overview
– COVID-19 Outbreak- Ready to Eat Rice Market, by Application [Supermarkets / Hypermarkets, Independent / Specialist Retailers, Restaurant and Hotels & Others]

– COVID-19 Outbreak- Ready to Eat Rice Industry Chain Analysis
– COVID-19 Outbreak- Ready to Eat Rice Market, by Type [, Indian Style, Chinese Style & Other Styles]

– Industry Manufacture, Consumption, Export, Import by Regions (2014-2019)
– Industry Value ($) by Region (2014-2019)

– COVID-19 Outbreak- Ready to Eat Rice Market Status and SWOT Analysis by Regions

– Major Region of COVID-19 Outbreak- Ready to Eat Rice Market
i) Global COVID-19 Outbreak- Ready to Eat Rice Sales
ii) Global COVID-19 Outbreak- Ready to Eat Rice Revenue & market share
– Major Companies List
– Conclusion

Thanks for reading this article; you can also get individual chapter wise section or region wise report version like North America, Europe or Asia.

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Electric Rice Cooker Market Explored By New Report For The Forecast 2019-2029

 

Electric Rice Cooker Market Explored By New Report For The Forecast 2019-2029

Growth Prospects of the Electric Rice Cooker Market

The comprehensive study on the Electric Rice Cooker Market provides crucial insights to the stakeholders who are vying to solidify their presence in the current and future market landscape. The various factors that are likely to shape the course of the Electric Rice Cooker Market over the next decade are thoroughly analyzed in the report.

The research report provides deep insights into the competitive outlook of the Electric Rice Cooker Market. The research report looks into growth strategies employed by key players, and how these strategies are poised to change the competitive dynamics in the Electric Rice Cooker Market over the forecast period. Further, our research reports include market share estimates and changing hierarchy in the Electric Rice Cooker Market over the forecast period. The influence of growth strategies on the changing hierarchy in the Electric Rice Cooker Market is also discussed in this report.

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Important doubts pertaining to the Electric Rice Cooker Market addressed in the report:

  • Which region is likely to provide promising opportunities for market players during the forecast period?
  • How are the economic policies in region 1 and region 2 favoring the growth of the Electric Rice Cooker market in these regions?
  • What are the recent manufacturing techniques that have gained popularity?
  • Why are companies increasing investments towards research and development?
  • Which product type is likely to remain a cash cow for manufacturers?

The extensive report fragments the Electric Rice Cooker market into multiple segments such as product type, regions, end uses, and industries.

The report provides an in-depth assessment of the numerous factors that are anticipated to impact the market dynamics with utmost precision and accuracy. The SWOT and Porter’s Five Forces Analysis provides a clear picture about the current operations of the various market players operating in the global Electric Rice Cooker Market.

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Competition Outlook

The market study provides valuable insights related to the major players involved in the Electric Rice Cooker Market. The study includes information related to the recent mergers, acquisitions, collaborations, product launches, and research & development activities.

The report covers exhaustive analysis on:

  • Market Segments
  • Market Dynamics
  • Market Size
  • Supply & Demand
  • Current Trends/Issues/Challenges
  • Competition & Companies involved
  • Technology
  • Value Chain

Regional analysis includes:

  • North America (U.S., Canada)
  • Latin America (Mexico, Brazil)
  • Western Europe (Germany, Italy, France, U.K., Spain)
  • Eastern Europe (Poland, Russia)
  • Asia Pacific (China, India, ASEAN, Australia & New Zealand)
  • Japan
  • Middle East and Africa (GCC Countries, S. Africa, Northern Africa)

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Analytical insights included in the report:

  • SWOT analysis of the major market players operating in the Electric Rice Cooker Market
  • Current and projected trends that are expected to influence the growth of the Electric Rice Cooker Market
  • Region-wise assessment of consumption patterns
  • The influence of research and development on the Electric Rice Cooker Market
  • Market size and value of the Electric Rice Cooker Market in different geographies

The report is a compilation of first-hand information, qualitative and quantitative assessment by industry analysts, inputs from industry experts and industry participants across the value chain. The report provides in-depth analysis of parent market trends, macro-economic indicators and governing factors along with market attractiveness as per segments. The report also maps the qualitative impact of various market factors on market segments and geographies.

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NEW RESEARCH REPORT ON LONG-GRAIN RICE SEEDS MARKET , 2019-2026

 

supriya September 2, 2020

The global Long-Grain Rice Seeds market study encloses the projection size of the market both in terms of value (Mn/Bn US$) and volume (x units). With bottom-up and top-down approaches, the report predicts the viewpoint of various domestic vendors in the whole market and offers the market size of the Long-Grain Rice Seeds market. The analysts of the report have performed in-depth primary and secondary research to analyze the key players and their market share. Further, different trusted sources were roped in to gather numbers, subdivisions, revenue and shares.

The research study encompasses fundamental points of the global Long-Grain Rice Seeds market, from future prospects to the competitive scenario, extensively. The DROT and Porter’s Five Forces analyses provides a deep explanation of the factors affecting the growth of Long-Grain Rice Seeds market. The Long-Grain Rice Seeds market has been broken down into various segments, regions, end-uses and players to provide a clear picture of the present market situation to the readers. In addition, the macro- and microeconomic aspects are also included in the research.

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Market Segment Analysis
The research report includes specific segments by Type and by Application. This study provides information about the sales and revenue during the historic and forecasted period of 2015 to 2026. Understanding the segments helps in identifying the importance of different factors that aid the market growth.
Segment by Type, the Long-Grain Rice Seeds market is segmented into
Japonica Rice
Indica Rice

Segment by Application
Agricultural Planting
Scientific and Research Planting

Global Long-Grain Rice Seeds Market: Regional Analysis
The Long-Grain Rice Seeds market is analysed and market size information is provided by regions (countries). The report includes country-wise and region-wise market size for the period 2015-2026. It also includes market size and forecast by Type and by Application segment in terms of sales and revenue for the period 2015-2026.
The key regions covered in the Long-Grain Rice Seeds market report are:
North America
U.S.
Canada
Europe
Germany
France
U.K.
Italy
Russia
Asia-Pacific
China
Japan
South Korea
India
Australia
Taiwan
Indonesia
Thailand
Malaysia
Philippines
Vietnam
Latin America
Mexico
Brazil
Argentina
Middle East & Africa
Turkey
Saudi Arabia
U.A.E
Global Long-Grain Rice Seeds Market: Competitive Analysis
This section of the report identifies various key manufacturers of the market. It helps the reader understand the strategies and collaborations that players are focusing on combat competition in the market. The comprehensive report provides a significant microscopic look at the market. The reader can identify the footprints of the manufacturers by knowing about the global revenue of manufacturers, the global price of manufacturers, and sales by manufacturers during the forecast period of 2015 to 2019.
The major players in global Long-Grain Rice Seeds market include:
DowDuPont
Bayer
Nuziveedu Seeds
Kaveri
Mahyco
RiceTec
Krishidhan
Rasi Seeds
JK seeds
Syngenta
Longping High-tech
China National Seed
Dabei Nong Group
Hefei Fengle
Gansu Dunhuang Seed
Dongya Seed Industry
Keeplong Seeds
Anhui Nongken
Beijing Doneed Seeds

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The Long-Grain Rice Seeds market research covers an exhaustive analysis of the following data:

  • Historical and future growth of the global Long-Grain Rice Seeds market.
  • Segmentation of the Long-Grain Rice Seeds market to highlight the growth prospects and trends impacting these segments.
  • Changing consumption behavior of customers across various regions.
  • Regional analysis on the basis of market share, growth outlook, and key countries.
  • Agreements, product launches, acquisitions, and R&D projects of different Long-Grain Rice Seeds market players.

The Long-Grain Rice Seeds market research addresses critical questions, such as

  1. Why is region surpassing region in terms of value by the end of 2029?
  2. How are the consumers using Long-Grain Rice Seeds for various purposes?
  3. Which players are entering into collaborations in the market of the Long-Grain Rice Seeds ?
  4. At what rate has the global Long-Grain Rice Seeds market been growing throughout the historic period 2014-2018?
  5. In terms of value, which segment holds the largest share?

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The global Long-Grain Rice Seeds market research considers region 1 (Country 1, country 2), region 2 (Country 1, country 2) and region 3 (Country 1, country 2) as the important segments. All the recent trends, such as changing consumers’ demand, ecological conservation, and regulatory standards across different regions are covered in the report. 


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